Protein Modification Reagents
Medchemexpress LLC Phenol-amido-C1-PEG3-N3 | 1096439-18-7 | 99.9% | 10 MG
Phenol-amido-C1-PEG3-N3 (PROTAC Linker 21) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules possessing Alkyne groups. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Azide group
- Facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules possessing alkyne groups
- Engages in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups
Genscript Corporation TEV Protease, His
Tobacco Etch Virus Protease is a highly site-specific cysteine protease that is found in the tags from fusion proteins. The optimal temperature for cleavage is 30°C; also it can be used at temperature as low as 4°C. It is recommended that the cleavage for each fusion protein be optimized by varying the amount of recombinant viral TEV protease, reaction time, or incubation temperature. It can be removed by Ni2+ affinity resin.The optimum recognition site for this enzyme is the sequence Glu-Asn-Leu-Tyr-Phe-Gln-(Gly/Ser) [ENLYFQ(G/S)] and cleavage occurs between the Gln and Gly/Ser residues, The most commonly used sequence is ENLYFQG. The protease is used to cleave affinity tags from fusion proteins. The optimal temperature for cleavage is 30°C. It is recommended that the cleavage for each fusion protein be optimized by varying the amount of recombinant viral TEV protease, reaction time, or incubation temperature. It can be removed by Ni2+ affinity resin.
Chemscene ChemScene | N3-PEG4-C2-Pfp ester | 250MG | CS-0105087 | 0.97 | 1353012-00-6| MFCD20926373 | 457.35
ChemScene | N3-PEG4-C2-Pfp ester | 250MG | CS-0105087 | 0.97 | 1353012-00-6| MFCD20926373 | 457.35
Medchemexpress LLC Mal-EGGGG-PEG8-amide-bis(deoxyglucitol) | 2360920-01-8 | C55H94N10O31 | 5 MG
Mal-EGGGG-PEG8-amide-bis(deoxyglucitol) is a cleavable ADC linker. This product is for research use only and has not been fully validated for medical applications.
- Target: ADC linker
- Pathway: Antibody-drug conjugate/ADC related
- Storage at -20°C, protected from light, and under nitrogen
- In solvent storage at -80°C for 6 months or -20°C for 1 month, protected from light and under nitrogen
- Soluble in H₂O at 100 mg/mL (71.87 mM) with ultrasonic assistance
AdipoGen Guanidine thiocyanate
Chemical. CAS 593-84-0. Formula CH5N3 . CHNS. MW 59.07 . 59.09. Guanidine thiocyanate is a powerful, chaotropic agent which is widely used for purification of proteins and nucleic acids. Guanidine thiocyanate is preferred for the purification of RNA because it dissociates the RNA into its nucleic acids and protein forms and is commonly used in the guanidinium thiocyanate-phenol-chloroform extraction method. As one of the strongest protein denaturants, it inactivates nucleases more than twice as fast as Guanidine hydrochloride. It is useful for denaturation and refolding of proteins. At high molarity solutions, Guanidine thiocyanate irreversibly inactivates RNase. Guanidine thiocyanate causes proteins to dissolve readily, thus disintegrating cellular structures.
Medchemexpress LLC Amino-PEG2-CH2CH2-SH (hydrochloride) | 3037676-58-4 | 95.0% | 201.71 g/mol | C6H16ClNO2S | 5 MG
Amino-PEG2-CH2CH2-SH (hydrochloride) is a PEG-based bifunctional linker for synthesis of PROTACs and conjugates. It features a primary amino group and a terminal thiol separated by a two-unit PEG spacer, supplied as the hydrochloride salt to aid stability and handling.
- Provides primary amino and terminal thiol functional groups for conjugation
- Two-unit PEG spacer offers flexibility and solubility
- Hydrochloride salt form improves stability and handling
- High purity suitable for synthetic applications
- Available in small milligram pack sizes for research use
Medchemexpress LLC Mal-amido-PEG4-NHS ester | 756525-99-2 | 99.2% | 513.50 | C22H31N3O11 | 100 MG
Mal-amido-PEG4-NHS ester is a PEG-based bifunctional linker containing a maleimide handle and an N-hydroxysuccinimide (NHS) ester. It provides a PEG4 spacer for flexibility and solubility and enables orthogonal conjugation to thiols and primary amines for use in PROTAC synthesis and bioconjugation applications.
- Provides a PEG4 spacer for increased solubility and flexible linker length.
- Maleimide group enables selective reaction with thiol groups for cysteine conjugation.
- NHS ester allows rapid coupling to primary amines under mild conditions.
- High purity suitable for synthetic and medicinal chemistry applications.
- Stable when stored at -20°C in solid form; follow solvent storage recommendations.
Broadpharm Azido-PEG4-amine | 951671-92-4 | MFCD20134134 | 5g
Azido-PEG4-amine | Putity: 98% | MW: 262.3 | 951671-92-4 | MFCD20134134 | 5g